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P-ISSN: 2349-8528, E-ISSN: 2321-4902   |   Impact Factor: GIF: 0.565

International Journal of Chemical Studies

Vol. 8, Issue 2 (2020)
Nyctanthes arbor-tristis mediated silver sulphide nano particles: Synthesis, characterization and anti-inflammatory activities

Author(s): Richa Kothari, Harleen Rathore and Akanksha Chaturvedi

Abstract: Silver sulphide nanoparticles (Ag2 S) are engineered nanoparticles with promising applications in industrial processes and have been used in infrared sensors, Solar cells optical filters and biomedical applications. Due to their low solubility Ag₂SNPs have been shown to be less toxic than AgNPs and Ag ⁺using aqueous extract of Nyctanthes-arbor- tristis leaves in the synthesis of silver sulphide nanoparticles is considered as green, eco-friendly, low priced biotechnology that gives importance over both chemical and physical method. In the present study the aqueous extract of fresh leaves of N. arbor tristis extract was used for green synthesis of silver sulphide nano particles plays a dual in nature in both reducing and stabilizing Ag 2 S NPS. In UV-Visible absorption, Fourier transform (FI-IR), XRD, Transmission electron microscopy (TEM), EDX and Scanning electron microscopy (SEM) were achieved for confirming and characterizing the biosynthesised Ag₂SNPs. TEM images of Ag₂SNPs detected the spherical Ag2 S NPS shape with diverse size range within 1.486-6.69nm. FT-IR analysis demonstrated the presence of free amino groups in addition to sulphur containing amino acid derivative actives as stabilizing agent as well as the presence of either sulphur or phosphorous functional groups which possibly attaches silver. In this study, biosynthesized N-Ag₂ S NPs exhibited anti-inflammatory activity against standard aspirin drug using protein denaturation, protease inhibition assay and heat induced haemolysis method as well as cytotoxic effects against skin cancer cell line A-431 cells gives IC5O (±0.11µg/ml).Haemolytic activity of Ag ₂SNPs was investigated and confirm as being non-toxic to human RBCs in low concentration.

DOI: 10.22271/chemi.2020.v8.i2a.8751

Pages: 42-54  |  1202 Views  24 Downloads

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How to cite this article:
Richa Kothari, Harleen Rathore, Akanksha Chaturvedi. Nyctanthes arbor-tristis mediated silver sulphide nano particles: Synthesis, characterization and anti-inflammatory activities. Int J Chem Stud 2020;8(2):42-54. DOI: 10.22271/chemi.2020.v8.i2a.8751
International Journal of Chemical Studies