Vol. 13, Issue 5 (2025)
An glycerol mediated catalyst free green and sustainable protocol for synthesis of Polyhydroquinolines under heating condition
Author(s): Yogesh Salve
Abstract: A facile, eco-friendly, and sustainable protocol has been developed for the synthesis of polyhydroquinoline derivatives via a one-pot multicomponent condensation reaction involving various substituted aromatic aldehydes, ethyl acetoacetate, dimedone, and ammonium acetate. Glycerol, a biodegradable and inexpensive by-product of the biodiesel industry, serves as both solvent and catalyst in this transformation. The present methodology offers several noteworthy advantages, including mild reaction conditions, excellent product yields, shorter reaction times, and a straightforward work-up process. Furthermore, the use of a non-toxic, metal-free, and recyclable medium underscores the environmental compatibility of this procedure. The operational simplicity, cost-effectiveness, and elimination of hazardous organic solvents make this protocol an attractive and sustainable alternative for the synthesis of polyhydroquinoline scaffolds.
Pages: 174-181 | 43 Views 26 Downloads
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How to cite this article:
Yogesh Salve. An glycerol mediated catalyst free green and sustainable protocol for synthesis of Polyhydroquinolines under heating condition. Int J Chem Stud 2025;13(5):174-181.
