Vol. 13, Issue 4 (2025)
Α-amylase inhibitory potential of Balanites roxburghiana Linn. fruit extracts: A comparative solvent-based study
Author(s): SP Soul Shekhar, ND Satyanarayan and CH Chandrashekhar
Abstract: The global prevalence of diabetes mellitus necessitates the exploration of novel therapeutic interventions with minimal adverse effects. This research evaluates the enzyme inhibitory properties of Balanites roxburghiana fruit extracts against ?-amylase using three different solvents (n-hexane, dichloromethane, and methanol) through chromogenic DNSA methodology. The investigation revealed remarkable variance in bioactivity among solvent extracts. n-hexane extract exhibited exceptional inhibitory capacity, demonstrating concentration-responsive effects with maximum inhibition of 90.10% at 500 ?g/mL, followed by 62.03% and 51.52% at 250 and 100 ?g/mL respectively. Dichloromethane extract showed limited bioactivity (4.86-7.29%), while methanol extract unexpectedly enhanced enzymatic activity. Acarbose served as reference standard with complete inhibition across all concentrations. Phytochemical evaluation identified steroids and saponins as predominant compounds in the active n-hexane fraction. These outcomes establish the therapeutic significance of lipophilic constituents in B. roxburghiana fruits for managing postprandial hyperglycemia.
DOI: 10.22271/chemi.2025.v13.i4b.12564
Pages: 102-106 | 339 Views 160 Downloads
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How to cite this article:
SP Soul Shekhar, ND Satyanarayan, CH Chandrashekhar. Α-amylase inhibitory potential of Balanites roxburghiana Linn. fruit extracts: A comparative solvent-based study. Int J Chem Stud 2025;13(4):102-106. DOI: 10.22271/chemi.2025.v13.i4b.12564
