Vol. 13, Issue 2 (2025)
Synthesis and biological activity of phenazine derivatives: Antibacterial and antifungal assessments
Author(s): T Karunakar, M Komal Reddy and K Raghava Raju
Abstract: Phenazine derivatives are known for their potent biological activities, particularly against microbial pathogens. In this study, a series of novel phenazine derivatives (4a-4e, 6a-6e, and 7a-7e) were synthesized and evaluated for their antibacterial and antifungal activities. The antibacterial potential was assessed using the Agar Plate Method against Staphylococcus aureus (Gram-positive) and Escherichia coli (Gram-negative), with ampicillin as the standard drug. At 100 µg/mL, ampicillin exhibited inhibition zones of 25 mm (S. aureus) and 16 mm (E. coli). Among the tested derivatives, 6e and 7e showed the highest antibacterial activity (12 mm inhibition against S. aureus), while 4d and 6a exhibited the maximum activity (12 mm inhibition against E. coli). The Minimum Inhibitory Concentration (MIC) values supported these findings, indicating a dose-dependent antimicrobial effect.
These findings highlight the promising antimicrobial potential of specific phenazine derivatives, suggesting their potential as lead compounds for future drug development. Further investigations into their mechanism of action and structural modifications could enhance their therapeutic efficacy.
Pages: 71-76 | 134 Views 71 Downloads
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How to cite this article:
T Karunakar, M Komal Reddy, K Raghava Raju. Synthesis and biological activity of phenazine derivatives: Antibacterial and antifungal assessments. Int J Chem Stud 2025;13(2):71-76.
