Vol. 13, Issue 1 (2025)

Adamantane is a weakly functional hydrocarbon commonly employed in the development of novel therapeutic agents. The structural and chemical characteristics of adamantane open new avenues for drug development. A key area of research focus is the advancement of novel adamantane based drug molecules with enhanced pharmacokinetic and pharmacodynamic properties. The adamantyl moiety is well-established as a crucial pharmacophore in biologically active compounds. Incorporating the adamantyl core into molecules can significantly influence their lipophilicity, pharmacological, and biological properties. Therefore, adamantane can effectively modify the therapeutic index of parent structures, making it widely utilized for diverse therapeutic applications.

In view of this, N’-(4-hydroxy-3-methoxy benzylidene) adamantane-1-carbohydrazide and its derivative were developed. They were synthesised and characterised using different spectroscopic methods. They were assessed for its in vitro antibacterial and antifungal properties. The dilutions inhibit growth of the test strains. The MIC was determined as the smallest concentration at which no growth was observed. Molecular docking was used for the prediction of mechanism of bactericidal and fungicidal activity confirming the experimental results. The study indicates that the synthesized compounds were well fitted in the active pocket of the targeted protein thus confirming antibacterial and antifungal activity.