Vol. 12, Issue 5 (2024)
Amaranthus phytochemicals as natural modulators of oxidative stress and eicosanoid metabolism
Author(s): Chinedu Okafor
Abstract: Amaranthus species are emerging as valuable sources of bioactive compounds with demonstrated potential in mitigating oxidative stress and regulating inflammatory responses. Oxidative stress is a pivotal factor in the onset of chronic diseases, while eicosanoid metabolism mediated by cyclooxygenase (COX) and lipoxygenase (LOX) enzymes represents a key pathway linking oxidative imbalance to inflammation. The present research investigates the phytochemical composition of Amaranthus tricolor and Amaranthus cruentus, focusing on their phenolic content, antioxidant activity, and ability to modulate COX-2 and 5-LOX activity. Methanolic extracts of both species were subjected to spectrophotometric, enzymatic, and computational analyses. Results revealed high total phenolic concentrations, significant radical scavenging capacity, and selective inhibitory effects on COX-2 and LOX enzymes. Docking studies confirmed strong interactions of rutin, quercetin, and betanin with enzymatic active sites, suggesting a molecular basis for their bioactivity. These findings underscore the potential of Amaranthus phytochemicals as natural modulators of oxidative stress and eicosanoid metabolism, supporting their development as nutraceutical candidates for inflammation-associated chronic disorders.
Pages: 202-209 | 100 Views 47 Downloads
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How to cite this article:
Chinedu Okafor. Amaranthus phytochemicals as natural modulators of oxidative stress and eicosanoid metabolism. Int J Chem Stud 2024;12(5):202-209.
