Vol. 12, Issue 5 (2024)
Recent advances in trifluoromethyl quinazoline derivatives: From antimalarial to antitumor applications
Author(s): Mahesh Y
Abstract: Quinazoline derivatives have gained significant attention recently due to their diverse biological activities, including anticancer, antiviral, antimicrobial, and antimalarial effects. Among these, trifluoromethyl quinazoline derivatives have emerged as a promising class of compounds with potent therapeutic potential. The trifluoromethyl group (-CF3) enhances the metabolic stability, lipophilicity, and bioavailability of these molecules, making them attractive for drug development. Trifluoromethyl quinazoline derivatives have been extensively studied for their antitumor properties, with several compounds showing remarkable efficacy in inhibiting cancer cell proliferation by targeting key cellular pathways, including tyrosine kinase inhibition and DNA intercalation. Notably, some derivatives have also been developed into effective antimalarial agents, contributing to the fight against drug-resistant strains of Plasmodium falciparum. Despite the progress in clinical applications, challenges such as drug resistance and side effects persist. Therefore, the discovery of new trifluoromethyl quinazoline compounds with improved efficacy and reduced toxicity remains a crucial research focus. This review highlights the recent advances in the synthesis, biological activities, and mechanistic insights of trifluoromethyl quinazoline derivatives, spanning from antimalarial to antitumor applications. We discuss key examples of FDA-approved quinazoline-based drugs, including gefitinib, erlotinib, and afatinib, and explore their relevance in addressing drug resistance. The ongoing efforts in this field aim to develop novel small-molecule anticancer agents that overcome resistance and offer safer alternatives to existing therapies. The incorporation of trifluoromethyl groups holds great promise for enhancing the therapeutic potential of quinazoline derivatives in modern drug discovery.
Pages: 144-149 | 137 Views 66 Downloads
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How to cite this article:
Mahesh Y. Recent advances in trifluoromethyl quinazoline derivatives: From antimalarial to antitumor applications. Int J Chem Stud 2024;12(5):144-149.
