Vol. 12, Issue 5 (2024)
Schiff base metal complexes: Advances in synthesis, characterization, and exploration of their biological potential
Author(s): Dr. Bansuri K Nandaniya, Dr. Siva Prasad Das, Divyesh R Chhuchhar, Mayur G Pithiya, Mayur D Khatariya, Dr. Darsan Jani and Dr. Kiran B Dangar
Abstract: Schiff base metal complexes are an important class of coordination compounds with significant biological relevance due to their ease of synthesis, structural versatility, and enhanced biological activity when coordinated with metal ions. Schiff bases, formed by the condensation of primary amines with carbonyl compounds, can act as bidentate or multidentate ligands, coordinating with transition metals such as copper, nickel, cobalt, zinc, and iron. This review discusses the design principles of Schiff base metal complexes, focusing on ligand modification strategies and the choice of metal ions, as well as synthesis methods and advanced characterization techniques. The biological activity of these complexes, including their antimicrobial, anticancer, antioxidant, and enzyme inhibition properties, is reviewed with a focus on structure-activity relationships. Additionally, the review highlights the therapeutic potential of these complexes, emphasizing their application in drug development, as well as their challenges and prospects in medicinal chemistry.
Pages: 131-134 | 633 Views 547 Downloads
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How to cite this article:
Dr. Bansuri K Nandaniya, Dr. Siva Prasad Das, Divyesh R Chhuchhar, Mayur G Pithiya, Mayur D Khatariya, Dr. Darsan Jani, Dr. Kiran B Dangar. Schiff base metal complexes: Advances in synthesis, characterization, and exploration of their biological potential. Int J Chem Stud 2024;12(5):131-134.
