Vol. 12, Issue 5 (2024)
Synthetic design of novel uracil and thiouracil derivatives
Author(s): Ambeu-Loko N’ta Christelle Mélissa, Glémoué Flié Hermann-Guy, Coulibaly Bamoro, Dosso Ouehi, Ouattara Logopho Hyacinthe, Kassi Amian Brise Benjamin and Fante Bamba
Abstract: We reported the synthesis of novel uracil and thiouracil derivatives by multicomponent reaction. The purification of molecules substituted in para position was easier and we obtained higher yields for these molecules. In addition, the yields of thiouracil compounds are higher than those of uracil compounds. All the synthesized compounds were characterized by 1H, 13C NMR and some more by FT-IR spectroscopy or LC-MS spectrometry. Compounds 5b, 5c and 5e underwent tautomerism in the pyrimidine core while compounds 5a, 5d, 6a, 6b, 6c, 6d and 6e promoted aromatization of this core.
DOI: 10.22271/chemi.2024.v12.i5b.12450
Pages: 125-130 | 187 Views 88 Downloads
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How to cite this article:
Ambeu-Loko N’ta Christelle Mélissa, Glémoué Flié Hermann-Guy, Coulibaly Bamoro, Dosso Ouehi, Ouattara Logopho Hyacinthe, Kassi Amian Brise Benjamin, Fante Bamba. Synthetic design of novel uracil and thiouracil derivatives. Int J Chem Stud 2024;12(5):125-130. DOI: 10.22271/chemi.2024.v12.i5b.12450
