Vol. 11, Issue 5 (2023)
Synthesise the novel pyrimidine derivative which is use as intermediate of the HIV drug
Author(s): Dr. Gajendra Kumar and Bipin Kumar Chaubey
Abstract: An efficient protocol is developed for the synthesis of Pyrimdine HIV intermediate 2-(4-cyanophenylamino) pyrimidin-4-yl-4-methylbenzenesulfonate via a simple two-step approach. Initially 4-[(4-Hydroxypyrimidin-2-yl) amino] benzonitrile was prepared by reacting 2-Methylthio-4-pyrimidinone with 4-Amino benzonitrile in Propionic acid. Then 4-[(4-Hydroxypyrimidin-2-yl) amino] benzonitrile was reacted with 4-Toluenesulfonyl chloride in presence of triethyl amine to generate the novel pyrimidine derivative 2-(4-Cyanophenylamino) pyrimidin-4-yl-methylbenzenesulfonate. This pyrimidine derivative afforded the target compound of HIV drug. The significant advantages of the method include cost-effectiveness, excellent yield and scope for large-scale production.
Pages: 50-53 | 518 Views 212 Downloads
download (7011KB)
How to cite this article:
Dr. Gajendra Kumar, Bipin Kumar Chaubey. Synthesise the novel pyrimidine derivative which is use as intermediate of the HIV drug. Int J Chem Stud 2023;11(5):50-53.
