Vol. 11, Issue 5 (2023)
Synthesis of 2-(4-aryl-1,3-thiazol-2-yl)-2,3- dihydrophthalazine-1,4-diones and comparative study of physicochemical properties of synthesized compounds and their Tautomeric forms
Author(s): Manju Mehta
Abstract: Phthalazine and Thiazole derivatives have been studied extensively for their broad-spectrum pharmacological, agricultural and biological activities. In the present paper, synthesis of 2-(4-aryl-1,3-thiazol-2-yl)-2,3- dihydrophthalazine-1,4-dione derivatives has been carried out by reaction of 2-hydrazinyl-4-aryl-1,3-thiazole with phthalic anhydride. The synthesized compounds were characterized by spectral analysis. Also, predictive evaluation of Physicochemical properties, like logP, logD, logS (intrinsic solubility), pKa (acidic and basic), microspecies distribution at different pH and HLB (hydrophilic-lipophilic balance), was carried out for synthesized compounds and their tautomer using Chem Axon chemicalize online software.
Pages: 37-42 | 221 Views 85 Downloads
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How to cite this article:
Manju Mehta. Synthesis of 2-(4-aryl-1,3-thiazol-2-yl)-2,3- dihydrophthalazine-1,4-diones and comparative study of physicochemical properties of synthesized compounds and their Tautomeric forms. Int J Chem Stud 2023;11(5):37-42.
