Vol. 11, Issue 4 (2023)
Synthesis of 1-(4-Aryl-1, 3-thiazol-2-yl)-1, 2- diazinane-3, 6-dione derivatives and their predictive physicochemical properties
Author(s): Manju Mehta
Abstract: Thiazoles and pyridazine derivatives belong to most versatile and active class of heterocyclic compounds. These have attracted special attention due to their immense biological, pharmacological, and agricultural activities. In the present communication, synthesis of 1-(4-aryl-1, 3-thiazol-2-y1)-1, 2-diazinane-3, 6-diones has been carried out by reaction of 2-hydrazinyl-4-aryl-1, 3-thiazole with succinic anhydride. The synthesized compounds were characterized by spectral analysis. Also, predictive evaluation of their Physicochemical properties, like logP, logD, logS (Intrinsic solubility), pKa (acidic and basic), microspecies distribution at different pH and HLB (hydrophilic-lipophilic balance), was carried out with Chem Axon chemicalize online server.
Pages: 23-27 | 314 Views 131 Downloads
download (10828KB)
How to cite this article:
Manju Mehta. Synthesis of 1-(4-Aryl-1, 3-thiazol-2-yl)-1, 2- diazinane-3, 6-dione derivatives and their predictive physicochemical properties. Int J Chem Stud 2023;11(4):23-27.
