Vol. 10, Issue 6 (2022)
Ultra-sonication aided synthesis of starch nano-particles from D Bulbifera and D Esculanta as potential pharmaceutical excipient.
Author(s): Obinna Ofoegbu, David C IKE, Chisom Obiakalusi and Anthony A Attama
Abstract: This study reports the synthesizing starch nanoparticles from two yam varieties and their evaluation as excipients for drug tableting. Starch particles were extracted from the yams by cold maceration with methanol and characterized for their phytochemical constituents and their physicochemical parameters. FITIR analysis was also carried out to identify the functional groups. Alkaline hydrolysis with ultrasonication was used to synthesize starch nanoparticles from the characterized starch. The synthesized starch nanoparticles were then applied as excipient for the tableting of paracetamol and compared to a standard (maize starch). The results obtained from the tableting test showed a weight uniformity (mg ± cv) of 597.5±1.2 and 595.5±1.2 for D. Bulbifera and D. Esculanta, respectively, a hardness (KGF ± SD) of 5.20±0.67 and 5.18 ± 0.67 for D. Bulbifera and D. Esculanta, respectively, a thickness (mm ± SD) of 5.68±0.04 for D. Bulbifera and 5.65±0.04 for D. Esculanta, and a disintegration time of (min ± SD) 4.5±1.56 for D. Bulbifera and 4.2±1.56 for D. Esculanta. A friability of 0.99 and 0.97 % for D. Bulbifera and D. Esculanta was also recorded, as was a hardness-friability ratio of 5.25 and 5.24 for D. Bulbifera and D. Esculanta. On comparison with the values obtained for the standard (maize starch), the two fabricated starch nanoparticles present competitive substituents for the tableting of paracetamol.
Pages: 52-59 | 404 Views 86 Downloads
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How to cite this article:
Obinna Ofoegbu, David C IKE, Chisom Obiakalusi, Anthony A Attama. Ultra-sonication aided synthesis of starch nano-particles from D Bulbifera and D Esculanta as potential pharmaceutical excipient.. Int J Chem Stud 2022;10(6):52-59.
