International Journal of Chemical Studies
  • Printed Journal
  • Indexed Journal
  • Refereed Journal
  • Peer Reviewed Journal
P-ISSN: 2349-8528, E-ISSN: 2321-4902   |   Impact Factor: GIF: 0.565

International Journal of Chemical Studies

Vol. 10, Issue 4 (2022)
Two polyketides: Biosynthetic transitional of Aplysiatoxin from a marine cyanobacterium Moorea producens


Author(s): Manish Kumar Jha, Nidhi Jha, Rajib Kumar Jha and Sanjeev Kumar Jha

Abstract: Aplysiatoxin and its derivatives have been isolated from marine cyanobacteria. The biosynthesis of their characteristic bicyclic skeletons from a linear polyketide intermediate has been proposed. Two polyketides, aplysiadione (1) and aplysiaenal (2), were isolated from the marine cyanobacterium Moorea producens (formerly Lyngbya majuscula) collected in the Sambalpur coastal area. The polyketide chemical structures were elucidated from HR ESI-MS and NMR spectra. Aplysiadione (1) corresponds to a decarboxylated analog of the proposed biosynthetic intermediate of Aplysiatoxin. Aplysiaenal (2) is a truncated analog of the linear intermediate. The isolation of aplysiadione (1) strongly supports the proposed ring formation mechanisms for the Aplysiatoxin, and this compound is a rare example of a biosynthetic intermediate of polyketide secondary metabolites from marine cyanobacteria.

Pages: 26-29  |  42 Views  7 Downloads

download (7616KB)
How to cite this article:
Manish Kumar Jha, Nidhi Jha, Rajib Kumar Jha, Sanjeev Kumar Jha. Two polyketides: Biosynthetic transitional of Aplysiatoxin from a marine cyanobacterium Moorea producens. Int J Chem Stud 2022;10(4):26-29.
International Journal of Chemical Studies