Vol. 10, Issue 1 (2022)
Synthesis of new Quinoline derivatives using Vilsmeier-Haack reagent: And its spectral characterizations
Author(s): Anant S Tekale
Abstract: To create substituted compounds, such as 2-chloro-3-formyl-8-methyl Via the Vilsmeier-Haack reagent, a very effective, straightforward, and practical technique for producing quinoline has been devised. This approach has high yields, uses less raw materials, and takes less time to complete the reaction. The substitution reaction by substituted acetanilide having an Ortho electron donating group and an ortho electron attracting group is explored in the current research effort, and it is good in all cases. Substituted quinoline and acetanilide are produced using the Vilsmeier reaction. Additional research is done on the substituted quinoline's nucleophilic substitution process. Similar to this, the -CHO (formyl) group in quinoline undergoes additional transformation into the 4'-NO2 nitro group, the 3'N-NH-C6H5 group, the 3'-CH3 group, and the 3'-N-benzylidene group.
Pages: 177-180 | 265 Views 131 Downloads
download (7314KB)
How to cite this article:
Anant S Tekale. Synthesis of new Quinoline derivatives using Vilsmeier-Haack reagent: And its spectral characterizations. Int J Chem Stud 2022;10(1):177-180.
