Vol. 9, Issue 5 (2021)
Phytochemical screening, acute oral toxicity, Analgesic effects and wound-healing activity of ethanolic and aqueous stem bark extracts of Pavetta owariensis P. Beauv.
Author(s): Sylla Tahiri, Worou Ranty Aime Mario and Dongui Bini Kouamé
Abstract: In a word, Pavetta owariensis (Rubiaceae) is one of the important medicinal plants using in the African pharmacopeia. The present study deals with the phytochemical analysis stem bark of Pavetta owariensis; alkaloids, anthraquinone, anthocyanins, catechic and gallic tannins, free quinone, saponins, sterols and polyterpenes, flavonoids, polyphenols and terpenoids are present in the extracts (AEPO and EEPO). Moreover, many researchers claim that its secondary metabolites obtained from phytochemical analysis are responsible for the pharmaceutical activity of plants. There is not much to be added apart from the fact no detailed scientific data are available regarding acute toxicity, analgesic effect and wound-healing activity of Pavetta owariensis. As no mortality and no adverse effects have been observed in animals, it can be concluded that the LD50 of AEPO and EEPO is greater than 2000 mg/kg body weight. Therefore, the plant studied can be consumed safely. Experiments have shown that AEPO and EEPO have analgesic properties in the same way as Acetaminophen. Ethanolic and aqueous stem bark extracts of Pavetta owariensis based on shea butter (AEPO_10% and EEPO_10%) were found to have significant healing activity which was evidenced by increase in the rate of wound contraction and skin-breaking strength.
Pages: 31-35 | 500 Views 32 Downloads
How to cite this article:
Sylla Tahiri, Worou Ranty Aime Mario, Dongui Bini Kouamé. Phytochemical screening, acute oral toxicity, Analgesic effects and wound-healing activity of ethanolic and aqueous stem bark extracts of Pavetta owariensis P. Beauv.. Int J Chem Stud 2021;9(5):31-35.