Vol. 8, Issue 4 (2020)
Synthesis and antiviral activity of 1-(n-substituted amino acetyl)-2-(5-substituted phthalimidomethyl) benzimidazoles
Author(s): Dr. Archana Jyoti
Abstract: Phthalic anhydride and 3-Nitro Phthalic anhydride were reacted with 2-aminomethyl benzimidazole in pyridine to give 2- (5-substituted phthalimidomethyl) bezimidazoles. These benzimidazoles were refluxed with chloroacetyl chloride in dry benzene followed by reaction with different secondary amines to give 1-(N-substituted amino acetyl)-2-(5-substituted phthalimidomethyl) benzimidazoles. Antiviral activity of these compounds was studied against Ranikhet Disease Virus (RDV) and Vaccinia Virus (VV). Some of these compounds have been found to be active against RDV.
DOI: 10.22271/chemi.2020.v8.i4a.10151
Pages: 14-16 | 1673 Views 316 Downloads
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How to cite this article:
Dr. Archana Jyoti. Synthesis and antiviral activity of 1-(n-substituted amino acetyl)-2-(5-substituted phthalimidomethyl) benzimidazoles. Int J Chem Stud 2020;8(4):14-16. DOI: 10.22271/chemi.2020.v8.i4a.10151
