Vol. 7, Issue 3 (2019)
Effect of cinnamon cassia extracts on hyperglycemia and renal function in Streptozotocin induced diabetic mice
Author(s): Amarnath Chaudhary, Ajeet kumar Jha, Rakesh Yadav, Kalyani Ray and Rakibul Islam
Abstract: Diabetes mellitus (DM) is defined as a group of metabolic diseases manifested by hyperglycemia which results from defects in insulin production and/or insulin action. The present study was conducted to investigate the effect of Cinnamon cassia extracts on hyperglycemia, and renal profile in Streptozotocin induced diabetic mice. Thirty six male Swiss albino mice were kept in six different groups with six mice in each group for 21days. Group T0 served as normal controls; Group T1 Streptozotocin induced 100 mg/ kg of body weight served as positive control mice,; Groups T2, T3 and T4 mice were also Streptozotocin induced 100 mg/ kg of body weight and mice treated with 300 mg/kg, 400 mg/kg and 500mg/kg of Cinnamon extracts (70% ethanol), respectively; and Group T5 were induced mice Streptozotocin 100 mg/ kg and treated with 5mg/kg Glibenclamide drug. The effect of extracts on hyperglycemia, and renal function were tested by chemistry analyzer. Results were analyzed using one way ANOVA at a 5% level of significance. The fasting blood glucose level was significantly (p<0.05) reduced at 400mg/kg and 500mg/kg of Cinnamon extract concentration as compared to the diabetic group. It also reduces urea and creatinine in induced diabetic mice. Reduction in the fasting blood glucose, urea and creatinine by Cinnamon extract indicates that it has anti-hyperglycemic, and renal failure restoration effect in Streptozotocin induced diabetic mice.
Pages: 2652-2657 | 274 Views 40 Downloads
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How to cite this article:
Amarnath Chaudhary, Ajeet kumar Jha, Rakesh Yadav, Kalyani Ray, Rakibul Islam. Effect of cinnamon cassia extracts on hyperglycemia and renal function in Streptozotocin induced diabetic mice. Int J Chem Stud 2019;7(3):2652-2657.
