Vol. 7, Issue 1 (2019)
Subacute dermal toxicity of Thermomyces sp. and Penicillium purpurogenum pigments in wistar rats
Author(s): R Poorniammal, S Prabhu, AR Sakthi and S Gunasekaran
Abstract: This research was focused to evaluate the dermal toxicity of yellow and red pigment isolated from Thermomyces sp. and Penicillium purpurogenum for textile application to assess its safety in experimental animals. Acute and sub-acute dermal toxicity studies were conducted on both sexes of wistar rats. Dermal application of Thermomyces sp and P purpurogenum at 0.5-5.0g/kg body weight to adult rat did not show any symptoms of toxicity or mortality of the rat. Dermal application of Thermomyces sp and Penicillium purpurogenum at 0.75-2.5% level (w/w) for 28 days did not produce any significant changes in body weight gain of the experimental rat compared to control rat. There were no significant differences in the relative weight of vital organs, hematological parameters and histopathological analysis between the experimental and control groups. The results clearly showed that acute and sub-acute dermal application of fungal pigment did not produce any toxic effects in male and female rats.
Pages: 630-634 | 680 Views 128 Downloads
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How to cite this article:
R Poorniammal, S Prabhu, AR Sakthi, S Gunasekaran. Subacute dermal toxicity of Thermomyces sp. and Penicillium purpurogenum pigments in wistar rats. Int J Chem Stud 2019;7(1):630-634.
