Vol. 7, Issue 1 (2019)
Antioxidative stimulation by di-and tri-organotin (IV) oximates against hepatic peroxidative stress in experimental animals
Author(s): Vikram Singh and Dr. Dharmendra Singh
Abstract: The antioxidative response of di- and tri-organotin (IV) oximates was examined in contrast to alcohol-induced hepatic peroxidative stress in experimental animals. The 30% alcohol (3.0 ml/150g b wt./day, PO, for 30 days) treated experimental animals have been found to be more susceptible to peroxidative stress as measured by thiobarbituric acid reactive species. After 30% alcohol induction to the experimental animals, the concentration of lipid peroxidation was significantly (p<0.001) higher in their hepatic tissues and serum, along with a concomitant significant (p<0.001) decrease in the levels of enzymatic antioxidants as SOD (superoxide dismutase), CAT (catalase), GPx (glutathione peroxidase), GR (glutathione reductase), GST (glutathione-s-transferase) in the hepatic tissues and, non-enzymatic antioxidants as GSH (reduced glutathione), Vit. C (ascorbic acid), Vit. E (tocopherol), ceruloplasmin, and β-carotene in the serum of treated animals as compared to normal controls. When these animals concomitantly received di- and tri-organotin (IV) oximates (compound-1, 2, 3, 4 & 5), at the dose level of 10 mg/kg b wt./day, PO, for 30 days, peroxidative stress was significantly minimal in both the hepatic tissues and serum, along with effectively inducing the antioxidative stimulation in the alcohol-treated animals. In conclusion, these results suggest the increased peroxidative stress in the hepatic tissues is likely to be associated with alcohol induction pathology, which could be reduced by di- and tri-organotin (IV) oximates mediated through interference with free radical generation along with stimulation of antioxidative action. Therefore, some of the di- and tri-organotin (IV) oximates might be promising as artificial antioxidants for curing hepatic peroxidative stress.
Pages: 443-448 | 195 Views 47 Downloads
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How to cite this article:
Vikram Singh, Dr. Dharmendra Singh. Antioxidative stimulation by di-and tri-organotin (IV) oximates against hepatic peroxidative stress in experimental animals. Int J Chem Stud 2019;7(1):443-448.
