Vol. 6, Issue 5 (2018)
Phylogenetic and comparative analysis of Drosophila melanogaster ecdysone receptor
Author(s): Gagan Rani, Neha Gupta, Neeru Singh Redhu and Sudhir Kumar
Abstract: Ecdysone receptor (EcR), a heterodimer of the EcR and Ultraspiracle (USP) nuclear receptors; helps in regulation, reproduction, larval molting, and metamorphosis. In insects, EcR is activated by ecdysteroids. USP nuclear hormone receptor of the insects orthologs to mammalian Retinoid X receptor (RXR) protein. Ecdysone receptor is target for a wide range of pesticides and insecticides. These insecticides binds to their respective target sites in turn hinder the activity of ecdysone and retard the growth of insects. The study was focused on phylogenetic and comparative study of Drosophila ecdysone receptor with its orthologs. Physiochemical properties such as molecular weight, theoretical isoelectric point, extinction coefficient, aliphatic index, instability index, total number of negatively and positively charged residues and grand average of hydropathicity were computed. Along with these physiochemical properties cellular localilization, no. of transmembrane helices, other proteins with which this protein interact and gene ontology were also depicted using various tools.
Pages: 2083-2091 | 492 Views 130 Downloads
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How to cite this article:
Gagan Rani, Neha Gupta, Neeru Singh Redhu, Sudhir Kumar. Phylogenetic and comparative analysis of Drosophila melanogaster ecdysone receptor. Int J Chem Stud 2018;6(5):2083-2091.
