Vol. 6, Issue 4 (2018)
Synthesis and characterization of some new cinnoline derivatives for its biological iterest
Author(s): Vishal Bharat Babar and Sudarshan Narayan Nagarale
Abstract: A series of pyrazolo[4,3-c]cinnoline derivatives was synthesized, characterized and evaluated for anti-inflammatory and antibacterial activity. Test compounds that exhibited good anti-inflammatory activity were further screened for their ulcerogenic and lipid peroxidation activity. Compounds 4d and 4l showed promising anti-inflammatory activity with reduced ulcerogenic and lipid peroxidation activity when compared to naproxen. Docking results of these two compounds with COX-2 (PDB ID: 1CX2) also exhibited a strong binding profile. Among the test derivatives, compound 4i displayed significant antibacterial property against gram-negative (Escherichia coli and Pseudomonas aeruginosa) and gram-positive (Staphylococcus aureus) bacteria. However, compound 4b emerged as the best dual anti inflammatory antibacterial agent in the present study.
Pages: 3387-3395 | 373 Views 136 Downloads
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How to cite this article:
Vishal Bharat Babar, Sudarshan Narayan Nagarale. Synthesis and characterization of some new cinnoline derivatives for its biological iterest. Int J Chem Stud 2018;6(4):3387-3395.
