Vol. 6, Issue 4 (2018)
Single blind placebo-controlled research study on plant seeds
Author(s): Shah Murad, Muhammad Ishaque, Adnan Shafique and Ejaz Fatima
Abstract: Coronary heart disease (CHD) is the single leading cause of death among American women, as it is among American men, even though CHD is less common and occurs later in life in women than men. In 2002, the prevalence of myocardial infarction (MI) in women was 3 million, and 3.3 million women had a history of angina pectoris; overall prevalence of CHD was 5.9 million. Every year, 345,000 women suffer a new or recurrent MI, and 241,600 women die of an MI. From 1970 to 2001, hospital discharges related to CHD for women increased 47%. Clearly, women, and particularly postmenopausal women, remain at high risk for coronary events—at least in part because women have been under-represented in clinical outcomes trials, tend to be undertreated in the clinical setting, and might be misdiagnosed when their presenting symptoms differ from those of men. This research work was single blind placebo-controlled, conducted at Jinnah Hospital, Lahore It was conducted from January 2017 to June 2017. Seventy five already diagnosed primary and secondary hyperlipidemic patients were selected with age range from 17 to 65 years. Diabetes mellitus, cigarette smoking/alcohol addictive patients, peptic ulcer disease, hypothyroidism, kidney dysfunction, any heart disease and liver disease. All patients were divided in three groups (group-I, group-II, group-III), 25 in each group. All participant’s baseline lipid profile data were taken and filed in specifically designed Performa, at start of taking medicine. Twenty five patients of group-I were advised to take 10 grams of Flaxseeds in three divided doses after meal. Twenty five patients of group-II were advised to take Ajwain seeds 10 grams in three divided doses after each meal for two months. Twenty five patients of group-III were provided placebo capsules, (containing grinded rice), taking one capsule after each meal. All participants were advised to take these medicines for eight weeks. Followup period: All participants were called fortnightly for their query and follow up. Their LDL-cholesterol, and HDL-cholesterol was determined at the hospital laboratory. In two months therapy by Flaxseeds decreased LDL-cholesterol from 195.11±2.11 mg/dl to 190.22±3.11 mg/dl, which is significant statistically. HDL was increased from 34.53±1.65 mg/dl to 38.97±2.29 mg/d, which is also significant change. In two months therapy by AJWAIN, LDL-c reduced from 201.51±2.62 mg/dl to 197.11±2.66 mg/dl, which is significant statistically. HDL-cholesterol increased by Ajwain from 36.97±3.32 mg/dl to 37.45±1.87 mg/dl, which is insignificant statistically. It was concluded from this study that Flaxseeds have more effect on HDL-c but Ajwain has lowest effect on this parameter.
Pages: 108-110 | 517 Views 51 Downloads
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How to cite this article:
Shah Murad, Muhammad Ishaque, Adnan Shafique, Ejaz Fatima. Single blind placebo-controlled research study on plant seeds. Int J Chem Stud 2018;6(4):108-110.
