International Journal of Chemical Studies
  • Printed Journal
  • Indexed Journal
  • Refereed Journal
  • Peer Reviewed Journal
P-ISSN: 2349-8528, E-ISSN: 2321-4902   |   Impact Factor: GIF: 0.565 NAAS Rating: 5.31 NEW

International Journal of Chemical Studies

Vol. 6, Issue 2 (2018)
Insilico physiochemical and structural characterization of hypopothetical proteins of Theileria annulata


Author(s): Pravas Ranjan Sahoo, Ramesh D, Bijayendranath Mohanty and Prakash Chandra Behera

Abstract: Theileria annulata is one important apicomplexon parasite which causes a serious disease such as tropical theileriosis in cattle. With advancement of bioinformatics and genetic sequencing, although lots of important protein of this parasite have been well characterized, but there are some hypopothetical proteins still existing needs to be physiochemically and structurally analyzed due to their high importance, through insilico platform. In this study, six hypothetical proteins were randomly selected and analyzed through in Pfam and CD Blast to find conserved domain in their structure. The physiochemical characters were characterized through EXPASY Protparam application programme and secondary, three dimensional structures were predicted through GORIV and SWISS homology modeling software tool respectively. It was found that the conserved domains from families like Der1, WD 40, AP2, and PA14 are present in this organism and maximum numbers of these proteins are found as stable, soluble and hydrophilic in nature that will provide a suitable therapeutic target against this parasite. The structural organization study revealed that these proteins contain abundant number of random coils followed by alpha helix and exist in monomer with low QMEAN Z score upon SWISS homology modeling. So this study would provide a better platform for the researchers to develop a suitable therapeutic strategy against Theileria annulata in docking studies in nearest future.

Pages: 1426-1429  |  300 Views  15 Downloads

download (4388KB)
How to cite this article:
Pravas Ranjan Sahoo, Ramesh D, Bijayendranath Mohanty, Prakash Chandra Behera. Insilico physiochemical and structural characterization of hypopothetical proteins of Theileria annulata . Int J Chem Stud 2018;6(2):1426-1429.
International Journal of Chemical Studies