International Journal of Chemical Studies
Vol. 6, Issue 2 (2018)
Deciphering physiochemical and structural characterization of p53 tumor suppressor protein in domestic animals through In silico approaches
Author(s): Pravas Ranjan Sahoo, Swagat Mohapatra, Gyanaranjan Sahoo and Prakash Chandra Behera
Abstract: The p53 is one important tumor suppressor protein involved in different cell processes such as DNA repair, apoptosis and cell cycle in domestic animals. Due to above importance, this protein needs to be characterized both in physiochemical and structurally for further exploration in modern biological research. In this study, the amino acid sequences of p53 protein of selected domestic animals were retrieved from NCBI site and various physiochemical parameters of this protein were compared among the selected domestic animals through different in silico programmes. The secondary and quaternary structure of this protein among the animals was also compared through homology modeling prediction method. It was found that this protein is an unstable, hydrophobic protein in all domestic animals with amino acids varied from 367 to 386 in number. The structural organization showed that this protein is a homo tetramer with number random coil (64%) followed by alpha helix (19%). So this study would provide a better platform for drug designer to develop new therapeutics against the cancer.
Pages: 254-257 | 549 Views 12 Downloads
How to cite this article:
Pravas Ranjan Sahoo, Swagat Mohapatra, Gyanaranjan Sahoo, Prakash Chandra Behera. Deciphering physiochemical and structural characterization of p53 tumor suppressor protein in domestic animals through In silico approaches. Int J Chem Stud 2018;6(2):254-257.