International Journal of Chemical Studies
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P-ISSN: 2349-8528, E-ISSN: 2321-4902   |   Impact Factor: GIF: 0.565

International Journal of Chemical Studies

Vol. 5, Issue 6 (2017)
Immunohistochemical diagnosis of metastatic myxoid chondrosarcoma in dogs


Author(s): M Thangapandiyan, Swati Choudhury, C Balachandran, K Jeyaraja and R Sridhar

Abstract: An 11 year old female Doberman was presented with the mass on the left forelimb. The animal was having clinical signs of lethargy, weight loss and decreased appetite for the past two weeks. Physical examination revealed hard painful swelling on the left humerus head region and the skin over the mass was normal. Radiographic examination of the head region of left humerus revealed irregular calcified areas and osteolytic changes. On necropsy, spherical, greyish-white, hard, varying sized (0.5-3.5cm) multiple nodules were noticed on the lungs, bronchial lymphnodes, heart, liver, spleen and kidney. Cytological examination demonstrated that round neoplastic chondroblasts with high variable nuclear to cytoplasmic ratios. Anisocytosis and anisokaryosis were marked. Histopathologicaliy, tumor mass present in humerus revealed pleomorphic cartilage lobules were separated by anaplastic spindle cells and vascularized fibro-connective stroma. Neoplastic cells revealed approximately 90% of positive cytoplasmic immunoreactivity with antibodies against vimentin and negative for cytokeratin.

Pages: 1569-1571  |  464 Views  15 Downloads

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How to cite this article:
M Thangapandiyan, Swati Choudhury, C Balachandran, K Jeyaraja, R Sridhar. Immunohistochemical diagnosis of metastatic myxoid chondrosarcoma in dogs. Int J Chem Stud 2017;5(6):1569-1571.
International Journal of Chemical Studies