International Journal of Chemical Studies
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P-ISSN: 2349-8528, E-ISSN: 2321-4902   |   Impact Factor: GIF: 0.565 NAAS Rating: 5.31 NEW

International Journal of Chemical Studies

Vol. 5, Issue 6 (2017)
Evaluation of hepatoprotective property of methanolic extract of Alternanthera sessilis in CCl4 induced hepatotoxicity in rats


Author(s): Anurag Borthakur, Pritam Mohan, Lalit Chandra Lahon, Dhruba Jyoti Kalita, Taibur Rahman and Arup Kumar Sharma

Abstract: A study was carried out to evaluate the hepatoprotective property of Alternanthera sessilis in CCl4 induced hepatotoxicity in rats. A total of 36 Wister rats were procured for the purpose of study, allotted into six different groups, having six numbers of animals in each. Group T1 was kept as negative control and fed standard basal diet for a period of four weeks. Group T2 was kept as positive control and subjected to CCl4 plus liquid paraffin (50% v/v) treatment at the rate of 2ml/kg body weight twice a week for three weeks. Group T3 was treated with Silymarin at 100 mg/kg body weight concurrently with CCl4 toxicity for four weeks. Group T4, T5 and T6 were treated with methanolic extract of Alternanthera sessilis at 100 mg/kg body weight, 300 mg/kg body weight and 900 mg/kg body weight respectively and concomitantly with CCl4 toxicity. Results revealed that there was significant decrease in the in the various hepatic biomarkers viz. ALT, AST, ALP, bilirubin in the methanolic extract of Alternanthera sessilis treated groups T4, T5, T6 as compared to the positive control group T2. Histopathological examination also showed that the hepatic damage induced by CCl4 toxicity was significantly reduced in the methanolic extract of Alternanthera sessilis treated groups. Thus it can be inferred that methanolic extract of Alternanthera sessilis has significant therapeutic effect on liver.

Pages: 471-474  |  486 Views  11 Downloads

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How to cite this article:
Anurag Borthakur, Pritam Mohan, Lalit Chandra Lahon, Dhruba Jyoti Kalita, Taibur Rahman, Arup Kumar Sharma. Evaluation of hepatoprotective property of methanolic extract of Alternanthera sessilis in CCl4 induced hepatotoxicity in rats. Int J Chem Stud 2017;5(6):471-474.
International Journal of Chemical Studies