Vol. 5, Issue 6 (2017)
Base catalyzed microwave assisted synthesis, characterization of 6-bromo-pyrazolo-[1, 5-a]-pyrimidine-3-ethyl-carboxylate& its biological evaluation as CDKs inhibitor
Author(s): Ganesh NY, D Nagaraja and U Chandrashekhar
Abstract: Nano-catalysts have been playing a great role in the synthetic chemistry for their function in the reactions to give higher yields when compared to the micro-catalysts, as well as, moment end of the reaction. So we focused on the attention to use different nano-catalysts for the synthesis of 5-ammino-pyrazole-4-ethyl-carboxylate (3). In order to follow green synthesis, microwave assisted synthesis was maintained by different types of base hydrolysis to afford 6-Bromo-Pyrazole- [1, 5-a]- Pyrimidine-3-Ethyl-Carboxylate (5). Instead of synthesizing different derivatives of compounds, different bases & nano-catalysts used to study the rate of the reaction & resulted successfully that it depends on the type of nano-catalysts & on the strength of the bases. We were characterized FT-IR, H1NMR & LC-MS. Later, the compound (5) was screened the biological activity & showed positive results by acting as inhibitor against Cyclin-dependent protein kinase (CDKs).
Pages: 81-87 | 1337 Views 50 Downloads
How to cite this article:
Ganesh NY, D Nagaraja, U Chandrashekhar. Base catalyzed microwave assisted synthesis, characterization of 6-bromo-pyrazolo-[1, 5-a]-pyrimidine-3-ethyl-carboxylate& its biological evaluation as CDKs inhibitor. Int J Chem Stud 2017;5(6):81-87.