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P-ISSN: 2349-8528, E-ISSN: 2321-4902   |   Impact Factor: GIF: 0.565 NAAS Rating: 5.31 NEW

International Journal of Chemical Studies

Vol. 5, Issue 5 (2017)
Multi component green synthesis of Bis-pyrrol indoline-2-ones triazoles catalysed by Cu NPs on activated carbon in water


Author(s): Dr. B Saritha, P Venkata Ramana, D Madhavi and LK Ravindranath

Abstract: A variety of potentially biological active multi component green synthesis of Bis-pyrrol indoline-2-ones triazoles possessing N- alkyl furan/ N- alkyl thiophene /N- alkyl pyrrol by catalysed Cu-NPs on activated carbon in water involving green synthetic technology have been developed. It involves in three steps. The first step involves the synthesis of 1-prop-2-ynyl indoline-2, 3-dione (3) from indoline -2, 3-dione and 3-chloropropanone (2). The intermediate1-prop-2-ynyl indoline-2,3-dione (3) was converted into 1-((1-furan/thiophene/pyrrol/phenyl/4-methyl phenyl/4-fluoro phenyl/4- trifluro methyl phenyl/4-nitro phenyl)-2-yl)methyl)-1H-1,2,3-triazol-4-yl)methyl)indiline-2,3-dione (5a-h) by 1,3-dipolar cyclo addition with 2-bromo methyl-1H-furan/ 2-bromo methyl-1H-thiophene/ 2-bromo methyl-1H-pyrrol benzyl bromide/4-methyl benzyl bromide/4-fluoro benzyl bromide/4-tri fluoro benzyl bromide/4- nitro benzyl bromide (4a-h) catalysed by Cu-NPs on activated carbon catalysed click reaction in neat water depicted in step-2. The step three involves green synthesis of 1-((1-furan/thiophene/pyrrol/phenyl/4-methyl phenyl/4-fluoro phenyl/4- trifluro methyl phenyl/4-nitro phenyl)-2-yl)methyl)-1H-1,2,3-triazol-4-yl)methyl) -3,3-di(1H-pyrrol-2-yl) indoline-2-ones (7a-h) from 1-((1-1-((1-furan/ thiophene/pyrrol/phenyl/4-methyl phenyl/4-fluoro phenyl/4- trifluro methyl phenyl/4-nitro phenyl)-2-yl)-2-yl)methyl)-1H-1,2,3-triazol-4-yl)methyl) indiline-2,3-dione (5a-h) and pyrrol (6) in presence of selected ionic liquid. The newly synthesized triazoles (7a-h) were characterized by spectral analysis. The synthetic route was shown in scheme-1. Antimicrobial activity of 7a-h was studied in presence of Ag NPs by disk diffusion method.

Pages: 2425-2431  |  439 Views  7 Downloads

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How to cite this article:
Dr. B Saritha, P Venkata Ramana, D Madhavi, LK Ravindranath. Multi component green synthesis of Bis-pyrrol indoline-2-ones triazoles catalysed by Cu NPs on activated carbon in water. Int J Chem Stud 2017;5(5):2425-2431.
International Journal of Chemical Studies