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P-ISSN: 2349-8528, E-ISSN: 2321-4902   |   Impact Factor: GIF: 0.565 NAAS Rating: 5.31 NEW

International Journal of Chemical Studies

Vol. 5, Issue 5 (2017)
β-Glucuronidase Inhibiting Constituents from C. casimiriana Duthie and Prain ex Prain. and Corydalis govaniana Wall


Author(s): Ram Lal Shrestha and Achyut Adhikari

Abstract:
Corydalis casimiriana Duthie and Prain ex Prain. and C. govaniana Wall. have been used in the treatment of scrofula, cutaneous infections, syphilis, along with diarrhea and dysentery. In the present work, phytochemical investigation of these two medicinal plants resulted the isolation of One tetrahydro-protoberberine type alkaloid, govaniadine (1); and six other alkaloids, caseadine (2), caseamine (3), protopine (4), stylopine (5), apocavidine (6), and fagarine I (7). β-glucuronidase enzyme plays a major role in generation of toxic metabolites, which may cause cancer in the intestine. Compound 1 showed a good β-glucuronidase (IC50 = 41.9 ± 3.1 µM) inhibition, better than D-saccharic acid 1, 4-lactone (IC50 = 45.8µM). Similarly, compound 2 showed significant inhibitory effect against β-glucuronidase (IC50 = 71.6 ± 4.3µM). Therefore, these compounds can be considered for further research for drug development to prevent tumors in intestine.

Pages: 700-701  |  431 Views  16 Downloads

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How to cite this article:
Ram Lal Shrestha, Achyut Adhikari. β-Glucuronidase Inhibiting Constituents from C. casimiriana Duthie and Prain ex Prain. and Corydalis govaniana Wall. Int J Chem Stud 2017;5(5):700-701.
International Journal of Chemical Studies