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P-ISSN: 2349-8528, E-ISSN: 2321-4902   |   Impact Factor: GIF: 0.565 NAAS Rating: 5.31 NEW

International Journal of Chemical Studies

Vol. 5, Issue 5 (2017)
Hepatoprotective effect of Cleome gynandra on Ehrlich Ascites Carcinoma in mice


Author(s): Jangyadutta Dash, SP Preetha, S Ramesh, M Parthiban, P Sriram, D Sakthivel and J Ranjith

Abstract:
Cleome gynandra has been widely used for many ailments in Ayurveda and Siddha system. In the present study the hepatoprotective effect of 70% ethanolic extract of Cleome gynandra (EECG) was investigated against Ehrlich Ascites Carcinoma (EAC) mice. Various antioxidant parameters like reduced glutathione (GSH), glutathione peroxidase (GPx), superoxide dismutase (SOD), lipid peroxidase (LPO) and catalase (CAT) were studied in the present communication. The hepatoprotective activity was also supported by histopathological studies of liver tissue. Treatment with EECG at 300 mg kg-1 for 10 days followed by tumor inoculation significantly reduced the impact of EAC on hepatocytes. The histopathology studies also supported that Cleome gynandra markedly reduced the effect of EAC on liver tissue near to normal. Thus the study reveals the potent hepatoprotective property of Cleome gynandra.


Pages: 565-568  |  443 Views  14 Downloads

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How to cite this article:
Jangyadutta Dash, SP Preetha, S Ramesh, M Parthiban, P Sriram, D Sakthivel, J Ranjith. Hepatoprotective effect of Cleome gynandra on Ehrlich Ascites Carcinoma in mice. Int J Chem Stud 2017;5(5):565-568.
International Journal of Chemical Studies