International Journal of Chemical Studies
Vol. 5, Issue 4 (2017)
Therapeutic potential of ndv-2k17 strain in canine mammary gland tumor
Author(s): Arup Das, M Shafiuzama, KG Tirumurugaan, R Sivashankar, M Shammi and BJ William
Abstract: Canine mammary tumor is the most common tumor in adult female dogs. Surgical intervention is the oldest and most widely accepted treatment option, even though it has limitations in presence of micro-metastasis and lymphatic invasion. Oncolytic viral therapy offers a new dimension in cancer treatment by eliminating malignancies by direct targeting and lysis of the cancer cells, leaving the noncancerous tissue unharmed. The present study was carried out to evaluate the therapeutic effect of Newcastle disease virus as an adjunct to surgical excision of canine mammary tumor. Six bitches under group-I having grade-III mammary tumor were subjected for four intravenous doses of purified Newcastle disease virus post operatively whereas, other six bitches under group-II also with grade-III mammary tumor were treated by surgical treatment alone. The six bitches of group-1, received the viral therapy, showed better result in terms of overall survivability and disease free survivability than that of the group-II bitches. Surgical treatment alone was not found to be sufficient in canine mammary tumors with lymph node metastasis. Hence, viral mediated therapy with Newcastle disease virus can be used as an adjunct to surgical excision in canine mammary tumor cases with metastatic lesion in the regional lymph nodes.
Pages: 605-609 | 566 Views 26 Downloads
How to cite this article:
Arup Das, M Shafiuzama, KG Tirumurugaan, R Sivashankar, M Shammi, BJ William. Therapeutic potential of ndv-2k17 strain in canine mammary gland tumor. Int J Chem Stud 2017;5(4):605-609.