Vol. 5, Issue 1 (2017)
Quinoline appended 1, 2, 3-triazole analogues: Synthesis, antimicrobial and docking evaluation
Author(s): R Gopi and S Senthil
Abstract: A series of quinoline appended 1, 2, 3- triazole derivatives were synthesized through cycloaddition of aromatic azides and 1, 4-diketone followed by pfitzinger reaction with isatin derivatives. Chemical structures of the derivatives were characterized by the various spectral techniques. The synthesized compounds were evaluated for their in vitro antimicrobial activity against three Gram positive and three Gram negative bacterial strains as well as four pathogenic fungal strains. The minimal inhibitory concentration and zone of inhibition were also determined. The compounds showed moderate to good biological activity. The obtained results encouraged the most active compounds could be useful as a template for future drug design, modification and exploration to produce more active analogs.
Pages: 208-216 | 1491 Views 137 Downloads
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How to cite this article:
R Gopi, S Senthil. Quinoline appended 1, 2, 3-triazole analogues: Synthesis, antimicrobial and docking evaluation. Int J Chem Stud 2017;5(1):208-216.
