Vol. 5, Issue 1 (2017)
Microwave assisted synthesis and antibacterial studies of 5-amino thiadiazole substituted pyrimidine compounds
Author(s): Karthic R, Andrews B and Subramani K
Abstract: Simple synthetic methods of 5-(5-amino-1,3,4-thiadiazol-2yl)-3,4-dihydro-6-methyl-4-phenylpyrimidin-2(1H)-thione (3f-j) are described. Compound 1 is converted to carbothiamide 2 by reacting compound 1 with thiosemicarbazide in catalytic amount of acetone is irradiated with help of domestic microwave oven (200W) for 2 minutes. Compound 2 is act as a key intermediate for the final compounds. The compound 2 is converted to corresponding thiadiazole 3 by treatment with conc.H2SO4 and NH3. Structural elucidation is accomplished by IR, 1H and 13CNMR, Elemental analysis and GC-Mass spectral data of the synthesized compounds. Few of these Pyrimidine derivatives have been evaluated for their possible antibacterial activity. Most of the tested compounds show significant antibacterial activity.
Pages: 204-207 | 1227 Views 51 Downloads
How to cite this article:
Karthic R, Andrews B, Subramani K. Microwave assisted synthesis and antibacterial studies of 5-amino thiadiazole substituted pyrimidine compounds. Int J Chem Stud 2017;5(1):204-207.