International Journal of Chemical Studies
Vol. 4, Issue 6 (2016)
Evaluation of Novel 2-Chloro Quinoline-3-Carbaldehyde derivatives
Author(s): Tekale AS, Shaikh SAL and Tirpude HA
Abstract: For the synthesis of substituted i.e. 2-chloro-3-formyl-8-methyl Quinoline an highly efficient, simple and convenient method through Vilsmeier-Haack reagent has been developed in high yields, less raw material, and less time requiring for completion of reaction. In the present research work the substituted quinoline and acetanilide are synthesized through Vilsmeier reaction has been reported to the substitution reaction by substituted acetanilide bearing electron donating group at ortho position and electron attracting group at ortho position are investigated and it is good in all case. Further, the nucleophilic substitution reaction of the substituted quinoline is also investigated. Similarly in quinoline the –CHO (formyl) group is subjected for further transformation of formyl group in to (4’-NO2 nitro group, 3’N-NH-C6H5) 3’-CH3 group and 3’-N-benzylidene group.
Pages: 95-98 | 1069 Views 36 Downloads
How to cite this article:
Tekale AS, Shaikh SAL, Tirpude HA. Evaluation of Novel 2-Chloro Quinoline-3-Carbaldehyde derivatives. Int J Chem Stud 2016;4(6):95-98.