International Journal of Chemical Studies
Vol. 4, Issue 5 (2016)
Evaluation of subacute toxicity of MSPC by intraperitoneal administration in albino rats
Author(s): Dr. Mohd. Amirul Islam, Dr. Sefaly Khatun and Syeda Ifteara Khanum
Abstract: Maleic Acid-Succinic Acid-Propane 1,2-diol Copolyester (MSPC) is a biodegradable copolyester synthesized from maleic acid and succinic acid in different mole combinations with 1 mole of propane 1,2-diol following Dean-stark apparatus using p-toluene sulphonic acid (Approximately 0.4% of the total weight) as catalyst and o-xylene as the reaction medium at temperature 140 °C for about 5 hours. MSPC was administered intraperitoneally to albino rats at a dose of 300 μg rat-1day-1 for 21 consecutive days in order to assessing the toxic effect of MSPC. The studies included the gross observation such as changes in body weight, haematological profiles, biochemical parameter of blood and histopathology of liver, kidney, heart, lungs and spleen of control group, and experimental group of rats. The changes in body weight, haematological and biochemical parameters are statistically insignificant after administration of MSPC when compared to that of control group, and experimental group of rats. No abnormalities were found in the histopathology of the liver, kidney, heart, lung and spleen in the experimental group of rats when compared with control group of rats. This study preliminary infers that Maleic Acid-Succinic Acid-Propane 1, 2-diol Copolyester (MSPC) is a safer biodegradable copolyester expected to be usable as an enteric coating materials or other purposes where biodegradable polymers be needed to use safely.
Pages: 134-139 | 1071 Views 8 Downloads
How to cite this article:
Dr. Mohd. Amirul Islam, Dr. Sefaly Khatun, Syeda Ifteara Khanum. Evaluation of subacute toxicity of MSPC by intraperitoneal administration in albino rats. Int J Chem Stud 2016;4(5):134-139.