International Journal of Chemical Studies
Vol. 4, Issue 5 (2016)
Synthesis and characterization of some New 4-Arylamino- and 4-Pyridynilamino-3-Nitro-2H--Benzopyran-2-ones and their antibacterial activity
Author(s): Ramiz Hoti, Hamit Ismaili, Naser Troni, Idriz Vehapi, Gjyle Mulliqi-Osmani, Veprim Thaçi and Arleta Rifati-Nixha
Abstract: Synthesis of the new substituted 3-nitro-2H--benzopyran-2-one derivatives is presented in this study. By condensation of 4-Chloro-3-nitro-2H-1-benzopyran-2-one 2 and corresponding arylamines 3(a-b), 4-(4’-carboxyphenylamino)-3-nitro-2H--benzopyran-2-one 4a and 4-(4’phenylsulphonylamino)-3-nitro-2H--benzopyran-2-one 4b are synthetized in high yield. Catalytic condensation of product 2 and pyridylamines 3(c-d), afforded novel substitued 4-pyridylamino-3-nitro-2H--benzopyran-2-ones 4(c-d). Alkali hydrolysis of 4(a-d) afforded the 2-hydroxy-ω-nitroacetophenone 5. The synthesized products are characterized on the basis of spectrometric data. Antibacterial activity of the compounds 4(a-d) against S. aureus, E. coli and Klebsiella was examined by measuring the inhibition zones around the disks marked with the corresponding product solutions in N,N-DMF concentration 2 mg/mL, 4 mg/mL and 6 mg/mL and results are submitted. Compounds 4c and 4a were more active against S. Aureus, 4d and 4c were more active against E. Coli whereas compound 4b showed considerable activity against Klebsiella.
Pages: 26-30 | 1249 Views 57 Downloads
How to cite this article:
Ramiz Hoti, Hamit Ismaili, Naser Troni, Idriz Vehapi, Gjyle Mulliqi-Osmani, Veprim Thaçi, Arleta Rifati-Nixha. Synthesis and characterization of some New 4-Arylamino- and 4-Pyridynilamino-3-Nitro-2H--Benzopyran-2-ones and their antibacterial activity. Int J Chem Stud 2016;4(5):26-30.