Vol. 4, Issue 5 (2016)
Synthesis, characterization and biological evaluation of novel 3-amino-1-(phenyl) benzo [f] quinoline-3-carbonitrile derivatives
Author(s): Hardas Der, Jasmin Kumbhani, Mukesh Patel, Kesur Ram, Deepkumar Joshi and Parimal Chatrabhuji
Abstract: A series of 3-amino-1(phenyl) benzo[f]quinoline-3-carbonitrile derivatives were synthesized by one pot Multi Component Reactions (MCRs) with different aromatic aldehyde, 2-Napthylamine and malononitrile using iodine and l-proline as catalyst. The main advantages for present high efficient method are short reaction time and higher yield. All of the synthesized compounds were characterized by FT-IR, 1H NMR, 13C NMR, Mass spectroscopy. Antibacterial and antifungal potential of the synthesized derivatives was studied against various bacterial and fungal strains respectively. Few derivatives were found to exhibit good antimicrobial activity.
Pages: 05-09 | 1800 Views 69 Downloads
download (2699KB)
How to cite this article:
Hardas Der, Jasmin Kumbhani, Mukesh Patel, Kesur Ram, Deepkumar Joshi, Parimal Chatrabhuji. Synthesis, characterization and biological evaluation of novel 3-amino-1-(phenyl) benzo [f] quinoline-3-carbonitrile derivatives. Int J Chem Stud 2016;4(5):05-09.
