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P-ISSN: 2349-8528, E-ISSN: 2321-4902   |   Impact Factor: GIF: 0.565 NAAS Rating: 5.31 NEW

International Journal of Chemical Studies

Vol. 4, Issue 5 (2016)
Synthesis, characterization and biological evaluation of novel 3-amino-1-(phenyl) benzo [f] quinoline-3-carbonitrile derivatives


Author(s): Hardas Der, Jasmin Kumbhani, Mukesh Patel, Kesur Ram, Deepkumar Joshi and Parimal Chatrabhuji

Abstract: A series of 3-amino-1(phenyl) benzo[f]quinoline-3-carbonitrile derivatives were synthesized by one pot Multi Component Reactions (MCRs) with different aromatic aldehyde, 2-Napthylamine and malononitrile using iodine and l-proline as catalyst. The main advantages for present high efficient method are short reaction time and higher yield. All of the synthesized compounds were characterized by FT-IR, 1H NMR, 13C NMR, Mass spectroscopy. Antibacterial and antifungal potential of the synthesized derivatives was studied against various bacterial and fungal strains respectively. Few derivatives were found to exhibit good antimicrobial activity.

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How to cite this article:
Hardas Der, Jasmin Kumbhani, Mukesh Patel, Kesur Ram, Deepkumar Joshi, Parimal Chatrabhuji. Synthesis, characterization and biological evaluation of novel 3-amino-1-(phenyl) benzo [f] quinoline-3-carbonitrile derivatives. Int J Chem Stud 2016;4(5):05-09.
International Journal of Chemical Studies