International Journal of Chemical Studies
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P-ISSN: 2349-8528, E-ISSN: 2321-4902   |   Impact Factor: GIF: 0.565 NAAS Rating: 5.31 NEW

International Journal of Chemical Studies

Vol. 4, Issue 4 (2016)
Influence of solid-state chemistry in drug substances in pharmaceutical products. A review


Author(s): KP Kadam and RP Chavan

Abstract: Most of Active pharmaceutical ingredients exhibits in different crystalline forms such as polymorphs, salts, solvates and hydrates and amorphous. Each forms exhibit polymorphism except amorphous. Crystal engineering approach presents a number of routes such as co-crystallization, polymorphism and salt formation to improve physico-chemical properties of drugs, which can be implemented through an in detail knowledge of crystallization processes and the molecular properties of drugs. Various polymorphs usually have different physic chemical, mechanical and thermal properties that can extremely affect the bioavailability, stability and other characteristics of the active pharmaceutical ingredients. Co-crystal is a binding of two molecules for enhancing drug pharmaceutical properties. All this solids form may affect Chemical and Physical Stability, Apparent Solubility, Dissolution, Bioavailability and Bioequivalence and Manufacturability of drug product, which require special attention during product development as it affects the quality, safety and efficacy of drug product.

Pages: 102-105  |  1190 Views  24 Downloads

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How to cite this article:
KP Kadam, RP Chavan. Influence of solid-state chemistry in drug substances in pharmaceutical products. A review. Int J Chem Stud 2016;4(4):102-105.
International Journal of Chemical Studies