International Journal of Chemical Studies
Vol. 4, Issue 4 (2016)
Influence of solid-state chemistry in drug substances in pharmaceutical products. A review
Author(s): KP Kadam and RP Chavan
Abstract: Most of Active pharmaceutical ingredients exhibits in different crystalline forms such as polymorphs, salts, solvates and hydrates and amorphous. Each forms exhibit polymorphism except amorphous. Crystal engineering approach presents a number of routes such as co-crystallization, polymorphism and salt formation to improve physico-chemical properties of drugs, which can be implemented through an in detail knowledge of crystallization processes and the molecular properties of drugs. Various polymorphs usually have different physic chemical, mechanical and thermal properties that can extremely affect the bioavailability, stability and other characteristics of the active pharmaceutical ingredients. Co-crystal is a binding of two molecules for enhancing drug pharmaceutical properties. All this solids form may affect Chemical and Physical Stability, Apparent Solubility, Dissolution, Bioavailability and Bioequivalence and Manufacturability of drug product, which require special attention during product development as it affects the quality, safety and efficacy of drug product.
Pages: 102-105 | 1337 Views 24 Downloads
How to cite this article:
KP Kadam, RP Chavan. Influence of solid-state chemistry in drug substances in pharmaceutical products. A review. Int J Chem Stud 2016;4(4):102-105.