International Journal of Chemical Studies
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P-ISSN: 2349-8528, E-ISSN: 2321-4902   |   Impact Factor: GIF: 0.565

Vol. 4, Issue 1 (2016)

Synthesis and biological evaluation of (E)-S-1H-benzo[d]imidazol-2-yl 2-benzylidene)hydrazinyl) ethanethioate derivatives


Author(s): Vikas A. Desai, Darpan B. Patel, Jitesh B. Patel

Abstract: We have developed a highly efficient approach for the preparation of S-1H-benzo[d]imidazol-2-yl 2-hydrazinylethanethioate 4 in acetic acid. Product 4 was further used for the synthesis of (E)-S-1H-benzo[d]imidazol-2-yl 2-substituted benzylidene)hydrazinyl) ethanethioate derivatives 6a-k under mild reaction condition. The synthesized compounds were further confirmed by IR, 1H NMR, 13C NMR and mass spectroscopy. All the synthesized compounds were screened for their biological activity against different strains of bacteria, fungi and antitubercular.

Pages: 54-60  |  2103 Views  242 Downloads

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How to cite this article:
Vikas A. Desai, Darpan B. Patel, Jitesh B. Patel. Synthesis and biological evaluation of (E)-S-1H-benzo[d]imidazol-2-yl 2-benzylidene)hydrazinyl) ethanethioate derivatives. Int J Chem Stud 2016;4(1):54-60.
 

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