International Journal of Chemical Studies
Vol. 3, Issue 3 (2015)
Synthesis of some 4- substituted-1- phenylpyrazole-5-one derivatives and study their biological activity
Author(s): Hamdan S. Al-Ebaisat
Abstract: In this study, a series of 4-[4-(3-Bromo-2oxo-4- substituted-phenylazetidin-1-yl) phenyl amino]-1,2-dihydro-2-ethyl-3- methyl-1- phenylpyrazole-5-one (IVA-H) was synthesized by Cyclocondensation of various Schiff bases of 4-[(4-aminophenyl) amino ]-1-ethyl-5-methyl-2-phenyl-1,2 -dihydro-3H-pyrazol-3-one with bromo- acetyl bromide in presence of triethylamine. various Schiff bases were synthesized by condensation of 4 -[(4-aminophenyl) amino]-1- ethyl-5-methyl-2- phenyl-1,2-dihydro - 3H-pyrazol-3-one with various arylaldehydes (IIIA-H). The structures of synthesized compounds were confirmed by Mass, IR, 1H NMR, and elemental analyses. In addition, the synthesized compounds were screened for their antimicrobial activities against S. aureus, P. aeruginosa, B. subtitles, E.coli and C. albicans, A. niger (Fungi). The results revealed that some of the obtained compounds exhibit anti-bacterial activity, that showed significant activity when compared with that of the commercially available.
Pages: 29-33 | 1148 Views 23 Downloads
How to cite this article:
Hamdan S. Al-Ebaisat. Synthesis of some 4- substituted-1- phenylpyrazole-5-one derivatives and study their biological activity. Int J Chem Stud 2015;3(3):29-33.