International Journal of Chemical Studies
Vol. 3, Issue 2 (2015)
Food chain exposure to heavy metals (cadmium and arsenic), effects on Plasma, tissue triglyceride concentration, experimental rats, a model study
Author(s): Chibueze Nwose, Kenneth C Nwachukwu, Michael P Okoh
Abstract: This study determined the effect of cadmium and arsenic acid containing diet on plasma and tissue triglyceride concentration using albino rats as model, monitoring its effect on body weight, organ/body weight ratio, respectively. Twenty eight albino rats weighing 150 - 200g) were used for the study. Diets containing cadmium or arsenic significantly decreased (P > 0.05) the body weight gain of rats. No significant difference (P>0.05) was observed in the liver/body weight ratio of rats in all the experimental groups. Significant change was not observed in the kidney or heart to body weight ratio in all the experimental groups. A significant increase was observed in plasma triglyceride level in rats fed cadmium containing diet as compared to the control group but no significant change was observed in plasma triglyceride of rats fed either arsenic or arsenic plus cadmium in diet. The liver triglyceride of the rats shows a significantly (P<0.05) increase relative to control in rats fed cadmium, arsenic and cadmium plus arsenic. A similar trend was observed in the heart of rats fed with cadmium and arsenic as the tissue glyceride was significantly increased as compared to control. Parallel analysis in the kidney shows significant (P<0.05) increase in triglyceride concentration in rats fed cadmium and cadmium plus arsenic containing diet. However, no significant change was observed in those fed arsenic-containing diet relative to control. Importantly, the study, contribute to the toxicity of these metals and brings to the fore, role of food chain in mammals exposure.
Pages: 102-108 | 890 Views 10 Downloads
How to cite this article:
Chibueze Nwose, Kenneth C Nwachukwu, Michael P Okoh. Food chain exposure to heavy metals (cadmium and arsenic), effects on Plasma, tissue triglyceride concentration, experimental rats, a model study. Int J Chem Stud 2015;3(2):102-108.