International Journal of Chemical Studies
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P-ISSN: 2349-8528, E-ISSN: 2321-4902   |   Impact Factor: GIF: 0.565 NAAS Rating: 5.31 NEW

International Journal of Chemical Studies

Vol. 1, Issue 4 (2013)
Synthesis and characterization of pyrimidine bearing 1, 3, 4-oxadiazole derivatives and their potential antifungal action


Author(s): Andrews B*, Mansur Ahmed

Abstract: A series of pyrimidine bearing 1, 3, 4-oxadiazole derivatives have been synthesized and evaluated for antifungal activity. All the structures of the newly synthesized compounds have been supported by IR, 1H-NMR, 13C-NMR, GC-MS and CHN analysis.  Most of the compounds have shown promising antifungal activity when compared with the standard drug amphotericin-B.

5-(5-amino-1,3,4-oxadiazol-2-yl)-3,4-dihydro-6- methyl-4-phenylpyrimidin-2(1H )-one 3a.
Fig. 1: 5-(5-amino-1,3,4-oxadiazol-2-yl)-3,4-dihydro-6- methyl-4-phenylpyrimidin-2(1H )-one 3a.

Pages: 32-39  |  1123 Views  20 Downloads

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How to cite this article:
Andrews B*, Mansur Ahmed. Synthesis and characterization of pyrimidine bearing 1, 3, 4-oxadiazole derivatives and their potential antifungal action. Int J Chem Stud 2013;1(4):32-39.
International Journal of Chemical Studies