International Journal of Chemical Studies
Vol. 1, Issue 3 (2013)
Solidification Behavior of Binary Alloys of Nicotinamide-P-Dimethylaminobenzaldehyde Drug System
Author(s): Vishnu Kant
Abstract: Solidification behaviour of Nicotinamide(NA)–p-Dimethylaminobenzaldehyde(MAB) binary drug system have been investigated and reported in this paper. The solid-liquid equilibrium (SLE) data determined by Thaw-melt method with their corresponding compositions construct the solid-liquid phase diagram which suggests simple eutectic of 0.857 mole fraction of MAB at 70 °C is followed by the binary system. The thermodynamic properties such as entropy of fusion, mixing and excess thermodynamic functions of all alloys (A1- A11) have been studied using their enthalpy of fusion values. Gibbs-Duhem equation resolves the quantitative identity of mixing chemical potential, activity and activity coefficient of a component in the binary mix. Interface morphology of the alloys follows the Jackson’s surface roughness (a) theory and predicts the faceted growth (a > 2) proceeds in all the alloys. The microstructure of pure components of taken binary system having high entropy of fusion as well as the binary organic eutectic of NA-MAB drug system has also been discussed in the present investigation.
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Fig. 1: Phase diagram of Nicotinamide-p-Dimethylaminobenzaldehyde system
Fig. 2: Graphical solution of partial molar enthalpy of mixing of MAB in binary mix
Fig. 3: Graphical solution of activity coefficient of MAB in binary mix
Pages: 34-41 | 1068 Views 1 Downloads
How to cite this article:
Vishnu Kant. Solidification Behavior of Binary Alloys of Nicotinamide-P-Dimethylaminobenzaldehyde Drug System. Int J Chem Stud 2013;1(3):34-41.