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P-ISSN: 2349-8528, E-ISSN: 2321-4902   |   Impact Factor: GIF: 0.565 NAAS Rating: 5.31 NEW

International Journal of Chemical Studies

Vol. 1, Issue 3 (2013)
Synthesis and Biological Activities of Fluoro Substituted Benzothiazole Derivatives


Author(s): S. Baluja *, K. Bhesaniya, R. Talaviya

Abstract: Some new fluorine substituted Benzo[d]thiazole derivatives have been synthesized and their characterization was done by IR, NMR and mass spectral data. The antibacterial activities of these synthesized compounds are done by agar well diffusion method at two different concentrations in DMF against some Gram positive and Gram negative bacteria. The antifungal activity of these synthesized compounds is also studied. It is observed that the synthesized compounds could inhibit both Gram positive bacteria only at higher concentrations and morpholine substitution is most effective. Against Gram positive bacteria P. mirabilis, only two compounds are found to be effective at higher concentrations and piperadine had no effect against this bacterium. All the compounds exhibited inhibition against fungal strain A. niger and morpholine substituent is most effective.

Antibacterial activity of Benzothiazole against [A] Gram-positive bacteria and [B] Gram-negative bacteria in DMF
Fig. 1: Antibacterial activity of Benzothiazole against [A] Gram-positive bacteria and [B] Gram-negative bacteria in DMF

Antifungal activity of Benzothiazole in DMF
Fig. 2: Antifungal activity of Benzothiazole in DMF

Antibacterial and antifungal activity of synthesized compounds against gram positive and gram negative bacteria in DMF
Fig. 3: Antibacterial and antifungal activity of synthesized compounds against gram positive and gram negative bacteria in DMF

Pages: 28-33  |  979 Views  12 Downloads

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How to cite this article:
S. Baluja *, K. Bhesaniya, R. Talaviya. Synthesis and Biological Activities of Fluoro Substituted Benzothiazole Derivatives. Int J Chem Stud 2013;1(3):28-33.
International Journal of Chemical Studies