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International Journal of Chemical Studies

Vol. 1, Issue 2 (2013)
Synthesis of some heterocyclic molecules from new benzoxazinones and quinazolinones


Author(s): Soliman E.A, Shaban M.E, Guirguis D.B, Gad E.S*

Abstract: The benzoxaxazinone 3 was prepared and treated with hydrazine hydrate, hydroxylamine hydrochloride, and o-phenylenediamine to give different quinazolinones 4,5 and benzimidazoles 6,7 respectively.Product 4 reacted with different aldehydes forming different Schiff’s bases 9,10a_e.Also it reacted with different Grignard reagents giving alcohols(11a,b) and ketones 11c,d, according to the bulkiness of the reagent. Finally, dibromo-, monobromoamino- and diamino-quinazolinones 12,13 a-d,&14 a-d were prepared upon addition of bromine to 4, followed by reacting different amines according to their molar ratios. Some benzoxazinone, and quinazolinone derivatives were tested for their antifungal and antibacterial activities and gave promising results.

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Scheme 1
Fig. 1: Scheme 1

Scheme 2
Fig. 2: Scheme 2

Scheme 3
Fig. 3: Scheme 3

Pages: 06-13  |  881 Views  9 Downloads

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How to cite this article:
Soliman E.A, Shaban M.E, Guirguis D.B, Gad E.S*. Synthesis of some heterocyclic molecules from new benzoxazinones and quinazolinones. Int J Chem Stud 2013;1(2):06-13.
International Journal of Chemical Studies