Vol. 4, Issue 6 (2016)
Evaluation of the cytotoxic effect of Malic acid-Butane 1,4-diol Copolyester in Albino Rats
Author(s): Dr. Mohd Amirul Islam, AFG Masud Rezaa, Dr. Sefaly Khatun and Dr. Iftekhar Ahmad
Abstract: MBC biodegradable co-polyester was synthesized from malic acid and butane 1,4-diol following Dean-stark apparatus using p-toluene sulphonic acid (Approximately 0.4% of the total weight) as catalyst. This copolyester was administered intraperitoneally to the rats at a dose of 300 g rat-1day-1 for 21 consecutive days in order to assessing the toxic effect of the polymer. The gross general observations such as changes of body weight, hematological profiles, biochemical parameters of blood and the histopathology of liver, kidney, heart, lungs and spleen were investigated both in control and experimental rats. The body weights of the rats were slightly increased. The changes of hematological and biochemical parameters were statistically insignificant. No abnormalities were found in the histopathology of the liver, kidney, heart, lung and spleen in the experimental group of rats when compared with control group of rats. From this study, it was inferred that malic acid-butane 1,4 -diol copolyester could be safely subjected to clinical trial for specialized application such as controlled and sustained release of drugs.
How to cite this article:
Dr. Mohd Amirul Islam, AFG Masud Rezaa, Dr. Sefaly Khatun and Dr. Iftekhar Ahmad. Evaluation of the cytotoxic effect of Malic acid-Butane 1,4-diol Copolyester in Albino Rats. 2016; 4(6): 38-43.